The genetic control of phenformin 4-hydroxylation.

نویسندگان

  • R R Shah
  • D A Evans
  • N S Oates
  • J R Idle
  • R L Smith
چکیده

Previously published results of phenformin 4-hydroxylation in 195 unrelated white British volunteers and 87 family members of 27 randomly selected probands have been subjected to genetic analysis. The results clearly show that about 9% of this population has a genetically determined defect in carrying out this oxidation reaction. The character for the defect is inherited in a Mendelian autosomal recessive fashion. The polymorphism shows a substantial degree of dominance.

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عنوان ژورنال:
  • Journal of medical genetics

دوره 22 5  شماره 

صفحات  -

تاریخ انتشار 1985